Codes P0021, P0345, U1000 and U1001, rattle noise on the engine?

The camshaft actuator can make the engine make a noise and do go out, but can you please shoot a quick video with your phone so I can hear the noise? That way I can tell for sure what's going on. You can upload it here with your response.

P0021: This code refers to a problem with the "A" camshaft position - timing over-advanced or system performance (Bank 2).

P0345: This code indicates a problem with the camshaft position sensor "A" circuit (Bank 2).

U1000: This is a network communication code.

U1001: Similar to U1000, this code also points to a communication issue in the network between control modules.

Let it be known that if the timing chains are off, they will make noise as well. Here are the camshaft timing oil control valves to make sure you replaced the correct one. Check out the images (below). Please let us know what happens.

Yes, that was what I replaced, how do I reset the camshaft actuator to be moderate i.e. not being over advance or over retarded but moderate?

The computer should do that via the oil control valve. Try clearing the codes and driving it.

I have replaced used actuator but the noise still remains, I replaced used cylinder head but still remain, I serviced the replaced actuator and put back, it still remains with P0021, from the live data of inlet valve bank 1 and 2, is it that timing is not correct or the oil control valve or the ECM?
I have shot the video, I uploaded the video, the screenshot of live data and screenshot of fault code that return.

The engine noise seems like the timing chain guide is broken or you have a broken piston. Also, the P0021: timing over-advanced or system performance (Bank 2) seems like the camshaft timing is off. Can you please recheck it?

Did you take time to review the Live Data Streaming I sent to you to see whether the inlet valve timing -9(-8.00;56) bank 1 and bank 2 27.56(-8.00;56) are not corresponding?
Also, the P0021: timing over-advanced or system performance (Bank 2) seems like the camshaft timing is off. Did you mean rechecking the timing marks on engine to see whether it all aligned with chain marks? If yes, I will tell you that I have checked that more than 5times using timing diagram from all data repair software.

Note: I replaced the 2-cylinder head, adjusters and chain guide but the noise still exist with P0021:always returned, I am looking at getting another ECM and program it and crank the vehicle and allow to idle for 30secs before rescanning the vehicle and see if that eliminates P0021, before it will be that the ECM is not sending the retard signal to oil control valve to eliminate the noise through oil pressure (hydraulically control mechanism).

Yes, I noticed the -9 that's why I wanted you to recheck the timing. Have you done a compression test? If the engine is not good the readings will never be correct. The engine noise has me concerned as well, are the camshaft lobes okay?

I wanted you to recheck the timing. Have you done a compression test? No, the engine starts at a crank.
That -9 is for inlet valve timing bank 1, which is not showing fault code, Then the (-8.00,56) is the correct valve timing parameter inlet valve bank 1 n'2.
Therefore, inlet valve timing parameter for bank2 is 27.50 but showing fault code while bank1 is -9 but not showing fault code, which one is correct among the two?
If the chain is stretched, don't you think it can cause this kind of noise or timing misalignment?

It sounds like you're dealing with a specific issue related to the timing and valve parameters on a 2005 Nissan Pathfinder.

Can you please send me a detailed timing diagram starting from oil pump mark to crankshaft sprocket key to chain mark and cylinder head marks?

Sure, here you go. Check out the images (below). Please let us know what you find.

I have taken time to recheck it and notice that the mark on the oil pump housing misaligned from crankshaft key and also exhaust camshaft bank1 deviates from top cylinder mark. If I align the gold mating mark on the chain to crankshaft sprocket mark, it will misalign but if I used teeth before the crankshaft sprocket mating mark to chain, it will align, what do you suggest?

Can you upload images so I can see what's going on?

I am looking at getting another ECM and program it and crank the vehicle and allow to idle for 30secs before rescanning the vehicle and see if that eliminates P0021.
I have done this test by getting another ECM and program and cranked it, but it didn't solve the problem but returned P0021. So, I will check the water-pump to see whether the bearing has broken leading to that noise and will also replace Oil Control Valve for bank2 to see if it eliminates P0021.

So far so good, I interchange the VVT Actuator from bank2 to bank1 and P0021 changes to P0011. I replaced the VVT actuator for bank1 and that fault code disappeared, but the rattling noise reduced remaining small.
Then the valve parameters for inlet valve timing bank1 drop from -9 to 0.5CA and bank2 drop from 27.50CA to 1.50CA.
Therefore, I still need to replace VVT actuator for bank2 and see if these valve parameters will correspond to 0.5 CA (camshaft angle) and eliminate the small noise remaining.
I attached the screenshot of live data of valve parameters after VVT actuator replacement bank1.
Note: I will mechanically adjust the two camshaft chain adjusters because when you turn the engine manually, you will notice that two adjusters will be pressing down and up thereby may be creating the noise.

Thanks for getting back to us on this, you are correct the bank2, so you need to replace VVT actuator.