2000 Chevy Express p0300 code after replacing intake manifo

2000 CHEVROLET EXPRESS
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AMT63
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Engine Performance problem
2000 Chevy Express V8 Two Wheel Drive Automatic 160k miles

The van was running fine and I finally decided to replace the leaking manifold gaskets. After getting it back together it would not start. After much T/S I replaced the fuel filter and now it starts but runs horribly and sets a p0300 code.
Nov 13, 2008 at 12:26 AM
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RASMATAZ
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P0300 Random Misfires can be caused by worn or fouled spark plugs, a weak spark (weak coil, bad spark plug wire), loss of compression, vacuum leaks, anything that causes an unusually lean fuel mixture (lean misfire), an EGR valve that is stuck open, dirty fuel injectors, low fuel pressure, or even bad fuel.
Nov 13, 2008 at 2:58 AM