Code p2422, vapor canister location and removal guide needed

The vent valve is located in the end of the canister under the vehicle. To access it you will need to remove the covers under the body of the truck. They use bolts and push pins to hold them in place. Remove both and clean all the dirt and crud that collects on and under them. With the cover off you will see the vapor canister and the valve mounted to the frame.
The valve twist locks into the end of the canister. Clean around it and then remove the electrical connector, Now test the circuit before you try to remove the valve. If the connector were corroded or the circuit faulty this is the time to find out instead of replacing the valve only to find it isn't the problem. Testing is simple if you have a scan tool as it can turn the valve on and off and you can use a simple test light to see if it works. As you likely don't have a scan tool that can control it we will test the valve instead. To do that you will need either a couple jumper leads connected to the battery or a 12 volt power source. With the electrical connector off just apply 12 volts the the two terminals on the valve. If it is working you should hear it click, as the code indicates it is stuck closed it shouldn't do anything if the code is correct. However it can be that the valve is working but the vent line is actually plugged, that would give the same result. To check it you will need to remove the valve by twisting it clockwise to remove it. Now you can see the port that goes to the vent line, if you use some compressed air you can blow through the vent to be sure it is open.
To replace the valve you simply apply a bit of silicone to the o-rings on it and push it into place and twist it back into the lock tabs, reconnect the plug and reinstall the covers.

Thank you Steve your guide and images helped me get the job done. Since I had already ordered and received the canister and vent valve, I figured I would replace both of them. No more emission system problems on my dashboard.

Great job. Always good to hear feedback and a successful outcome.

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Helpful post because it pointed out that the canister was under that panel. The bolts were easy to remove but the obnoxious push-in tensioners got destroyed on removal. I would add the vent valve is located on the southern side of the canister (which is more the shape of a rectangular pan of cornbread these days) and that the canister is roughly under the driver's seat on the underside of the 2013 Acura RDX I was fixing.

Two things puzzled me: The old valve didn't rotate to unlock. It just pulled right out. The new one went in and a twist-lock tab kind of seated into a groove in a rubberish molding around the opening. But because of that groove, there was no way to rotate the new valve either. Not sure what to think there.

Puzzling Thing No.2 was that there was liquid gasoline on the old valve. If it failed and was stuck closed, perhaps that's normal?

Normally, if you find any liquid fuel in there it is due to someone who tries to "top up" the tank by adding fuel after the pump clicks off. That lets the fuel get into places it shouldn't.
As for the rotation, there are multiple changes made to vehicles over the years, some documented and some only become known when you need to do repairs.