what is the problem help me

Check for plugged catalytic converter, check fuel pump pressure, if the check engine light is on, have the computer scanned for trouble codes. Most parts stores will do it for free.

The light is on and I have the codes but they can't tell me what exactly is wrong first it was misfire cylinders 1 and 3 now its cylinders 1 and 6 I don't get it.

Wow. That makes it difficult because many things can cause a misfire. When was the last tune up? Have you ever tried fuel injection cleaner? Have you checked fuel pump pressure? Has anyone checked the crank sensor?

Injector cleaner didn't work I changed spark plugs and wires and the coil pack, how do I check fuel pressure and could it be bad injectors or not.

To check fuel pump pressure, go to our homepage under the DIY section. There is a video and directions. As far as an injector, sure. If it isn't firing fuel correctly, it will cause a miss. However, it is odd that it is changing cylinders.

I have heard the EGR valve can cause it to misfire at different times the code that comes up is p0300

Yes, the egr can. THe PO300 is a general code for multi cylinder misfire. Check the EGR. Check for carbon build up in both the intake and EGR valve itself. If clean, see if the plunger moves when vacuum is applied and make sure the valve has a clean full seat when closed.

Ok new development my engine light went off for about an hour and the van ran so much better but my battery connection got loose and almost came off as soon as I fixed that the light popped back on and started running bad again what's ur thoughts?

Was the battery disconnected?

No it was really loose thou cuz I put a new battery in last week

Make sure the wiring from the battery to the fuse box is in good condition.

I found the problem spark plug 1 gap was closed completely and spark plug 6 had a cracked porcelain in it thanks for the help thou